Recessive lethal deletion on mouse chromosome 7 affects glucocorticoid receptor binding activities.

An interstitial deletion of chromosome 7(q35).

We describe a patient with developmental delay, mild dysmorphic features, and monosomy of 7q35. Only one other patient with an interstitial deletion of this band has been previously reported. A review of clinical features of these two children did not show similarities in dysmorphic features. Reports of patients with other 7q interstitial deletions are listed.

Transcriptional Regulation of the Mouse IL-7 Receptor Promoter by Glucocorticoid Receptor

Identification of an Xiap-Like Pseudogene on Mouse Chromosome 7

The most thoroughly characterized mammalian IAP is XIAP/BIRC4, which can inhibit caspases 9, 3 and 7, but may also regulate apoptosis through interactions with other proteins such as Smac/DIABLO, HtrA2/Omi, XAF1, TAK1, cIAP1, and cIAP2.High throughput sequencing of the mouse genome revealed the existence of a gene resembling Xiap/Birc4 on mouse chromosome 7. To confirm the existence of this gen...

Glucocorticoid receptor phosphorylation in mouse L-cells.

This paper summarizes our observations on the phosphorylation state of untransformed and transformed glucocorticoid receptors isolated from 32P-labeled L-cells. The 300-350-kDa 9S untransformed murine glucocorticoid receptor complex is composed of a 100-kDa steroid-binding phosphoprotein and one or possibly two units of the 90-kDa heat shock protein (hsp90), which is also a phosphoprotein. Tran...

A QSAR evaluation of glucocorticoid receptor binding

Exposures to environmental concentrations of endocrine disrupting compounds are now a known threat to both human and ecological health. In the current study capabilities for structure-activity modeling incorporated in the platform QSAR Toolbox were employed for investigation the binding effect of set of chemicals toward glucocorticoid receptor. A total of 39 steroidal ligands were split in cate...